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Leflunomide: mode of action in the treatment of rheumatoid arthritis

Neuroscience 44 (3), 585590

This barrier disruption can contribute to the translocation of luminal PAMPs into the systemic circulation, further amplifying inflammatory responses across the inter-organ axes

It acts by activating the HGF/c-Met signaling pathway, which plays a critical role in forming new synaptic connections and enhancing neuroplasticity

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