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Although additional studies are required to clarify the molecular mechanisms responsible for hyperhomocysteinemia-induced vascular disorders, there is evidence that the direct cytotoxicity of markedly elevated homocysteine and/or of its oxidized by-products (homocysteine thiolactone, homocysteine sulfinic acid, and homocysteic acid) damages endothelial cells (Dudman et al, 1991

PMID 22141380

M., Aparisi, L., Serra, M

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However, noticeable effects like improved sleep typically appear within 1-2 weeks, while body composition changes usually become apparent around weeks 6-8