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Telomere attrition is a hallmark of replicative senescence and genomic instability, particularly in highly mitotic tissues 4

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In REDEFINE 1, adults with obesity or overweight (without diabetes) treated with CagriSema had a mean body weight reduction of 20.4% at 68 weeks under the treatment-policy estimand, compared with 3.0% on placebo

Ileal protein carbonyls, as marker of protein oxidation, were measured by an ELISA according to the method of Buss et al