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Furthermore, post-hoc analyses of SUSTAIN 6 and PIONEER 6 combined revealed a HR of 0.76 for the effect of semaglutide versus placebo on overall MACE, driven mainly by the effect on nonfatal stroke [95]

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For weekly formulations like tirzepatide, discontinuation was typically advised at least one week before surgery, accounting for the medication's half-life of approximately 5 days

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