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CONFLICTS OF INTEREST MPL and FS hold a minority interest in Lunella, Inc

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

Prader-Willi Syndrome (PWS), a severe neurogenetic syndrome with uncontrollable hyperphagia and high threshold for pain, is an excellent example of this issue

Neuroscience 388:357366 Ghawi SK, Methven L, Niranjan K (2013) The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var

Patients with demanding professional responsibilities or frequent social commitments may prefer dosing on days when they have greater flexibility to manage potential side effects