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However, although GLP-1 receptor agonists are known to produce modest but statistically significant weight loss in patients with diabetes mellitus, our knowledge of how endogenous GLP-1 regulates food intake and body weight remains limited

For example, mutations in skin barrier-related genes (such as filaggrin) can lead to increased transdermal water loss and downregulated expression of tight junction proteins, thereby enhancing the skins permeability to MPs

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