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Regulatory approvals and inclusion in clinical guidelines bolster their credibility

Proc Natl Acad Sci USA 106:91099114 Maughan SC, Pasternak M, Cairns N, Kiddle G, Brach T, Jarvis R, Haas F, Nieuwland J, Lim B, Muller C, Salcedo-Sora E, Kruse C, Orsel M, Hell R, Miller AJ, Bray P, Foyer CH, Murray JAH, Meyer AJ, Cobbett CS (2010) Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

a 2012 European study of 1,031 people recorded only 2 reactions to it (a rate of 0.19%)

Other risk factors include older age and higher melanin levels (darker skin pigment), which can reduce vitamin D production from sunlight

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