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This was the first study to systematically demonstrate that tirzepatide not only induces substantial weight loss but also shows improvements in sleep-disordered breathing among obese individuals

This effect may be particularly pronounced in patients experiencing rapid weight loss

However, a long-term exploratory RCT in 150 people with obesity found that differences in eating disorders psychopathology scores were not maintained at 52 weeks when liraglutide in combination with behavioral therapy was compared with behavioral therapy alone 215

Dehydration can cause headaches, fatigue, and constipation, all of which mimic or worsen GLP-1 side effects

Brennan PJ, Brigl M, Brenner MB