Given that calcimimetics, which activate the CaSR are already FDA approved and used in patients, these existing agents might be repurposed or redesigned as anti-obesity drugs
Tirzepatide, as the first GLP-1/GIP dual receptor agonist, demonstrated greater benefits in blood glucose control and weight reduction compared with GLP-1 single receptor agonists like semaglutide and dulaglutide, induced by the combined activation of both receptors.23,26 The latest results from the SURMOUNT-5 trial, published in May 2025, indicate that in obese individuals without diabetes, tirzepatide led to greater reductions in both weight and waist circumference compared with semaglutide
These results suggest that from 6 to 12 h after GalN injection, the ROS-eliminating system in the liver of proline group was significantly activated than that of control group, probably with the most significant difference at 12 h
10.1007/s40265-020-01435-4 Drugs
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