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Although robust evidence is lacking for the primary prevention of cardiovascular disease using a combination of SGLT2is and GLP1-RAs, meta-analyses suggest potential benefits

10.1038/emm.2013.47 62 IqbalA

DOI: 10.1136/bmj.s325 Never miss a breakthrough: Join the SciTechDaily newsletter

Individual considerations of risks and benefits, acknowledging that many of these are unknown for those without obesity, should also be done with a trained medical professional

The adverse effects of DPP-4is are mainly related to gastrointestinal tract discomforts (e.g., nausea, diarrhea), pancreatitis, and skin reactions (e.g., rash, angioedema, pruritus) [82]