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Study Design and Participant Selection This exploratory secondary analysis was conducted within a randomized, placebo-controlled clinical trial involving adults aged 18 to 65 years with obesity, defined as a body mass index between 32 and 43 kg per square meter, and without diabetes mellitus

9 Furthermore, the accumulation of free radicals damages the biological components of proteins, lipids, and DNA, as it breaks down single and double strands of DNA, degrades nitrogenous bases, and transforms and cross-links DNA with proteins

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For individuals with a significant B-12 deficiency, B-12 injections are typically administered weekly until levels normalize