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Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on cardiovascular and renal outcomes in patients with type 2 diabetes: A cohort study

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These combined effects help regulate blood glucose levels more effectively whilst promoting weight loss in many patients

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The reduction of the mitochondrial [NAD + ]/[NADH] during DR (Hagopian et al., 2003) decreased SIRT4 activity as well as its ADP-ribosylation of GLUD1, preserving GLUD1 activity (Pannek et al., 2017)