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Because these medications slow gastric emptying, researchers often observe: Nausea and vomiting Diarrhea or constipation Decreased appetite In early studies, Retatrutide has shown a slightly higher frequency of these side effects compared to Tirzepatide, likely due to the increased potency of the triple-receptor activation

Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age

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Given the large number of women for whom these drugs are currently prescribed, these findings are of immediate clinical relevance and they heighten the need to better understand and ultimately mitigate this heightened susceptibility