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152 The CRR encompasses coordinated adaptations across cardiac cell types and extracellular components, implemented through four key therapeutic approaches, each tailored to specific patient subgroups: (1) Supposing inflammatory remodelingtargeting the interleukin-1 (IL-1) and interleukin-6 (IL-6) signaling pathways has become a promising strategy, with IL-1/IL-6 inhibitors demonstrating anti-inflammatory and cardioprotective effects in clinical trials for recurrent pericarditis and atherosclerotic cardiovascular diseases (ASCVDs)