Detoxifies electrophilic agents Eliminates reactive oxygen species (ROS) and reactive nitrogen species (RNS) Maintains the essential thiol redox state of proteins Maintains metal ion homeostasis and regulates key cellular processes -L-Glutamyl-L-cysteinyl-glycine A tripeptide composed of glutamic acid, cysteine, and glycine The most abundant non-protein thiol compound in various cells
Galdieri, L., Zhang, T., Rogerson, D., Lleshi, R
Later, PTPN22, located on 1p13, is the last immunoregulatory gene identified in the disease
Glutathione peroxidase (GPx) supports this system by catalyzing the reduction of hydrogen peroxide and lipid peroxides using GSH (Krishnamurthy et al., 2024)
Areas after the contiguous tail were considered noise and excluded from the analysis by thresholding objects above 40,000 pixels in area for the area analysis