While people on GLP-1s do lose a lot of weight, 15-40% of the weight lost is actually lean muscle mass
Furthermore, in smaller studies of patients with recent acute and advanced HF, irrespective of T2D status (62, 63), treatment with liraglutide was associated with a nonsignificant increase in CV mortality and hHF (30%, P = 0.17) (62)
Eur J Clin Invest 54(12):e14292 Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH et al (2023) 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the management of patients with chronic coronary disease
This delay in the action of the stomach can lead to symptoms like nausea, vomiting, bloating, early fullness, and abdominal pain
Protein-induced GLP-1 secretion is poorly understood but appears to play a role in GLP-1-mediated satiety [260]