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1,2 Researchers have examined potential biomarkers, such as carnitine (3-hydroxy-4-N-trimethylaminobutyrate), which is proposed to be a conditionally essential nutrient, 3 with its primary role being to transport long-chain fatty acids from the cytosol to the mitochondrial matrix, where they undergo -oxidation to produce energy

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Because the two peptides hit two separate receptors that both feed the same GH pulse, they are described in research as synergistic rather than additive: GHRH-driven and secretagogue-driven signals combine at the pituitary

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