Adjustments to insulin therapy may be necessary to maintain glycemic control
This mechanism makes it effective for both men and women, particularly in addressing conditions like hypoactive sexual desire disorder (HSDD)
Concomitantly administered means that the two drugs are taken at, or nearly at, the same time
By activating GIP receptors, tirzepatide enhances insulin secretion and may improve insulin sensitivity, while GLP-1 receptor activation stimulates glucose-dependent insulin release, suppresses inappropriate glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways
GLP-1 receptor agonists stimulate insulin release from the pancreas only when blood glucose is elevated, suppress glucagon (which reduces liver glucose production), and slow gastric emptying to moderate glucose absorption after meals