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The binding of T3 to TRs induces a conformational change in the receptor, which allows the receptor to bind to thyroid hormone response elements (TREs, specific DNA sequences) in the promoter regions of target genes (Simons 2003)

398,399 Mild mitochondrial uncoupling with 2,4-dinitrophenol (DNP) reduces oxidative stress and improves mitochondrial function in PD and HD models

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