Three non-coding mutations in the HGF gene were found at the autosomal-recessive NSHI locus (DFNB39) in some Pakistani and Indian families (Schultz et al., 2009)
Growth hormone production peaks in adolescence and declines through adulthood, and IGF-1, the downstream messenger that drives muscle protein synthesis and tissue repair, declines along with it
Li X, Liu Z, Xu S, Ma X, Zhao Z, Hu H, et al
Most are mild and short-lived: injection-site soreness, warmth, or redness
This is a crucial issue in part because patients who discontinue use of GLP-1s tend to regain much or all of the weight they lost while taking the drug, according to several studies, including a meta-analysis by researchers at Englands University of Oxford