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Pojer, K

Research Insights NNMT & Obesity Pathways NNMT has been identified as a key regulator of adipose tissue metabolism

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Abbreviations ALS: Amyotrophic lateral sclerosis ANG: Angiogenin APS: Antigen-presenting cells BLBP: Brain lipid binding protein CHG: Chromogranin CNS: Central nervous system CCL2: Chemokine (CC motif) ligand 2 CCR2: Chemokine receptor-2 DRG: Dorsal root ganglia EAAT: Excitatory amino acid transporter fALS: Familial amyotrophic lateral sclerosis FGF-1: Fibroblast growth factor 1 FUS/TLS: Fused in sarcoma/translocated in liposarcoma GDNF: Glial cell line-derived neurotrophic factor GFAP: Glial fibrillary acidic protein GRPs: Glial-restricted precursors HSC: Hematopoietic stem cells LPS: Lipopolysaccharide MHC: Major histocompatibility complex mSOD1: Mutant superoxide dismutase 1 NGF: Nerve growth factor NSC: Neuronal stem cell OPTN: Optineurin PFN: Profilin PSA-NCAM: Polysialylated neural cell adhesion molecule RC2: Radial glial cell marker-2 sALS: Sporadic amyotrophic lateral sclerosis SDF-1/CXCR4: Stromal cell-derived factor 1/chemokine receptor 4 TDP-43: TAR DNA-binding protein 43 Teffs: CD4(+)CD25() T lymphocytes TLR: Toll-like receptor Tregs: CD4(+)CD25(high) T lymphocytes VCP: Valosin-containing protein References Gordon PH (2011) Amyotrophic lateral sclerosis: pathophysiology, diagnosis and management

When these pro-inflammatory mediators reach the hypothalamus, they increased the levels of oxidative stress and neuronal inflammation in the hypothalamus through processes such as microglia proliferation ( Figure 2 )