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Digestive Sensitivities Some people may experience mild digestive upset, such as bloating or nausea, when starting a new supplement
Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively
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Combination approaches that pair GSH depletion with ferroptosis induction, immunotherapy, or chemotherapy may help overcome resistance, while standardized manufacturing and rigorous toxicity evaluation will be critical for regulatory approval