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The most common retatrutide side effects are nausea (28%), diarrhea (24%), constipation (21%), and vomiting (17%), with symptoms peaking around weeks 6-8 before substantially improving by week 12
Discontinuation rates were significantly lower for patients with type 2 diabetes (46.5% [95% CI, 46.2%-46.9%] by 1 year and 64.1% [95% CI, 63.7%-64.5%] by 2 years) compared with patients without type 2 diabetes (64.8% [95% CI, 64.4%-65.2%] by 1 year and 84.4% [95% CI, 84.0%-84.8%] by 2 years) (Figure 1A)
This can occur due to conditions such as pernicious anemia, gastrointestinal disorders like Crohns disease, or following gastrointestinal surgery
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