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A more recent hypothesis postulates that high-dose folic acid redirects the active form of vitamin B12 in serum, i.e., holotranscobalamin, either toward the bone marrow to support reticulocyte synthesis that is induced by folic acid in B12-deficient patients, or into the urine in which it is excreted instead of being taken up and recycled into circulation through the kidneys (84)

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B vitamins are enzyme cofactors that play an important role in energy metabolism

Inside the brain, ALCAR donates its acetyl group to choline via choline acetyltransferase (ChAT) to form acetylcholine, the primary neurotransmitter of the cholinergic system