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IGF-1 DES shows moderately reduced IGFBP affinity, with greater selectivity it particularly reduces affinity for IGFBP-1, IGFBP-2, and IGFBP-4, but retains more binding to IGFBP-3 than IGF-1 LR3 does

[25] [26] Appropriate ophthalmological monitoring is advisable in those with pre-existing retinopathy

Yu X, Tang H, Huang L, Yang Y, Tian B, and Yu C

While most studies focused specifically on cirrhosis, a small subset addressed chronic liver disease without cirrhosis, including nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and chronic hepatitis

Understanding these changes can help patients prepare for the transition and recognise what is normal during this period