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However, it is not known whether vitamin B 12 supplementation, in addition to folic acid supplementation, may be beneficial in the prevention of NTD (62) randomized controlled trials are needed to address this question

Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states

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And the science is not ambiguous