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By enhancing intracellular hydroperoxides, especially hydrogen peroxide, decreasing reduced glutathione concentration, increasing cysteine oxidation, and activating protein kinases, oxidant stress can enhance the activity of transcription factors, such as the nuclear factor kappa B and activator protein-1, which are involved in the expression of cell surface adhesion molecules, growth factors, immunoreceptors, and cytokines

Cancer Chemother Pharmacol 37:363370 Halliwell B (2007) Biochemistry of oxidative stress

Some ingredients do cause a warm sensation such as magnesium and some can cause a person to move toxins in your body and can make you initially feel a little off

10.2478/acph-2019-0045 129 MalhotraD.Portales-CasamarE.SinghA.SrivastavaS.ArenillasD.HappelC.et al (2010)