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Naltrexone, when prescribed, may be compounded at lower than FDA-approved doses as part of a clinical protocol and should not be used by individuals taking opioids, as it can cause sudden opioid withdrawal
Additionally, the effects on renal function, such as changes in eGFR, appear to be reversible upon discontinuation, suggesting a hemodynamic rather than structural mechanism
Some providers prescribe off-label in this band, but Second Nature doesnt, because the clinical evidence weakens significantly below BMI 27
Methods This was a retrospective cohort study of adult patients with a body mass index (BMI) 30 kg/m 2 prescribed GLP-1 analogue therapy at an obesity specialist clinic in Vancouver, Canada
Clinical trial data from the SURMOUNT and SURPASS programs did not show dramatic differences in efficacy between abdominal, thigh, and upper arm injections for the majority of participants
