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Mishra K, Khatib N, Barasch D, Garti S, Garti N, Kakhlon O (2024) A new tailored nano-droplet carrier of astaxanthin can improve its pharmacokinetic profile and antioxidant efficacy

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The accumulated ROS in cells interacts with Ca 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload (91)