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145 The pectin coating protected the NPs during gastric transit and enabled localized release in the colon via microbial pectinase degradation, while collagen IV targeting enhanced NP adhesion to injured colonic tissues

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Dihexa, with its combined N-hexanoic-Tyr-Ile-(6) aminohexanoic amide structure, exhibited a significantly extended half-life of 335.5 9.5 min, confirming that both N- and C-terminal modifications are effective strategies for improving metabolic stability [2]