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The top panel shows the 20% reduction in the composite primary endpoint (cardiovascular death, nonfatal heart attack, or nonfatal stroke), with curves separating early and maintaining divergence throughout the nearly 40-month follow-up period

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Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue

While gut bacteria metabolize LC into TMA, which is then converted to TMAO in the liver, these derivatives have distinct metabolic pathways and bioavailability, which may influence the amount of TMAO levels [32, 48, 49]

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