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Other modalities have emerged as potential therapeutic options in patients with clinically localised PCa, including high-intensity focused US, cryo-therapeutic ablation of the prostate (cryotherapy), focal padeliporfin-based vascular-targeted photodynamic therapy, and focal RT by brachytherapy or CyberKnife

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Separately, Pfizer entered a $2.085B deal with YaoPharma (Dec 2025) for a GLP-1 asset, and a $495M deal with Sciwind Biosciences (Feb 2026) to commercialize ecnoglutide in China

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Mortality was captured in all analyses as a result of diabetes-related complications (based on UKPDS Outcomes Model 2 data) and background mortality based on UK-specific, cause-subtracted life tables published by the World Health Organization [18, 22, 23]