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Oral thrush, increased risk of infection, and heart-related effects are among the most frequently reported concerns

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Gallbladder events rise modestly, especially with rapid loss. Less common signals include skin dysesthesia, which is now on the label, and a small thyroid-cancer association in two population studies with a tiny absolute event rate. Depression and suicidality remain unproven

Pulmonary embolisms are most frequently caused by clots that originate in a deep vein

Hormone profile and age change expected responses Older men often have lower baseline testosterone and altered LH/FSH dynamics, so peptides that modestly boost gonadotropin release may work differently than in younger men