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Valuable energy is then wasted to put them back together

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Experimental models demonstrate that FOXO proteins mediate the inhibitory effects of insulin/IGF on target genes and are essential for maintaining metabolic homeostasis

For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks