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This oxidized iron then binds to transferrin (TF) in the plasma, forming holotransferrin, which is subsequently taken up by cells via TfR1-mediated endocytosis ( 3+ is subsequently reduced to Fe 2+ by the metalloreductase six-transmembrane epithelial antigen of the prostate 3 (STEAP3), followed by its transport into the cytosol via DMT1 to join the labile iron pool (LIP) or be stored in ferritin (Yan et al., 2021

When it comes to NAD here at Perfect B, we decided to use a protocol where our patients use 5 subcutaneous injections a week for up to 6 weeks, instead of IV infusions