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Potential Benefits of Retatrutide Phase 2 data reported approximately 24% mean body weight reduction over 48 weeks at the highest dose, alongside improvements in HbA1c, waist circumference, and lipid profiles, though Phase 3 confirmation is required before firm conclusions can be drawn

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A conditional Met -transgenic mouse was also generated, showing that the enhancement of MET levels in neurons selectively delays the disease onset in ALS mice models, prolonging lifespan, retarding motor neuron loss, and ameliorating motor performance (Genestine et al., 2011)

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