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Publication age and reagent-literature bias Much of the foundational, peer-reviewed pharmacology of Long R3 IGF-1 dates from the late 1980s and 1990s, when the analog was developed as a tool for dissecting IGFBP-versus-receptor contributions to potency and for biotechnology applications such as cell-culture media

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Together, they address both the thinning and the dryness of mature skin in parallel

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