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An open-label uncontrolled trial including 27 patients with T2D and NAFLD treated with liraglutide 0.9 mg/day for 24 weeks showed a trend toward increases in liver-to-spleen attenuation ratio assessed by CT scan and, more importantly, a significant improvement in histological inflammatory scores in 10 subjects undergoing liver biopsies after a prolonged treatment of 96 weeks (64)

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Y seguimos a ambos grupos durante tres aos

At nine and twelve months the distribution continued to shift modestly, with 33% still showing further improvement, and 20% and 21% worse than their pre-GLP-1 level, respectively

The JAK-STAT signaling pathway is highly conserved across evolution and primarily consists of the ligand-receptor complex, the JAK family, and the STAT family