In mammals, paracetamol is detoxified in the liver where, at low doses, sulfation and glucoronidation result in the formation of the inactive, non-toxic sulfate and glucuronid conjugates (Scheme 1)
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2), blood plasma is filtered in the glomerulus, a bundle of porous capillaries lined by a membrane and specialized epithelial cells, that allows solutes and waste, including drugs and their metabolites, and water to pass through while ensuring larger substances, such as blood cells and proteins, remain in the circulatory system (Holechek 2003)