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This high energy demand creates a byproduct of oxidative stress

Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

Abnormal iron metabolism is a significant trigger for ferroptosis, with iron-related proteins including transferrin receptor protein 1 (TfR1), ferritin (FTH and FTL), and iron export proteins playing essential roles in iron homeostasis

It was shown that Fer-1 inhibited Shen-Qi-Ling-Bi Decoction (SQLB)-induced ferroptosis in HCT116 and HT29 cells and reversed the protein levels of Nrf2, GPX4, and SLC7A11 32