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The current paradigm to address non-pulmonary vein sources of AFib is to extend the ablation to include more atrial tissue, which has had limited success

However, a common off-label approach is to start with the same initial dose as for diabetes management, i.e., 0.25 mg weekly for the first 4 weeks, then increase to 0.5 mg weekly, and potentially up to 1 mg or more based on the patient's response and tolerance