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Importantly, patients using transdermal medications should avoid exposing the patch to external heat sources such as heating pads, electric blankets, hot tubs, saunas, or prolonged direct sunlight, as heat can increase drug absorption and potentially cause overdose

The study could not find any correlation between changes in GLP-1 levels and changes in body weight, IBS, or gastrointestinal symptoms

21 If pregnancy is achieved, emerging evidence has linked obesity-related epigenetic alterations in sperm to changes in offspring metabolic health, such as insulin resistance and increased body weight, as well as possible neurobehavioural changes and disease susceptibility

For example, a major trial published in The New England Journal of Medicine reported greater average weight loss among participants receiving semaglutide compared with placebo

The average age of the participants was 46.7 years