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If approved, it is expected to drive new standards of care and intensify competition within the evolving IgAN treatment landscape

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Because the brand, diagnosis, and approved use matter, product selection affects approval

Indeed, in transfected HEK293 cells expressing the same levels of GLP-1R or GIPR, and at two vastly different receptor densities (obtained with either 0.5 mg or 10 mg receptor cDNA transfections), it was determined that GLP-1R induced the formation of approximately double the amount of cAMP the GIPR induced, with the surface expression (B max ) levels being equal for both receptors [42]