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In heart failure patients, greater than 50% increases in BUN were observed in 16.6% of valsartan-treated patients compared to 6.3% of placebo-treated patients [see Warnings and Precautions (5.4)]

Brent A McLean, Chi Kin Wong, Jonathan E Campbell, David J Hodson, Stefan Trapp, Daniel J Drucker Endocrine Reviews , First published online on December 15, 2020, bnaa032 Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and gut motility, supporting development of GLP-1 receptor (GLP-1R) agonists for the treatment of diabetes and obesity

Proc Biochem 41:15011505