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Based on the National Survey on Drug Use and Health from 2013, it was estimated that 43.8 million of all adults in the USA had any mental illness in 2012 and 10 million had serious mental illness.In 2013, 15.7 million of all adults in the USA were affected by a major depressive episode over the past 12 months (National Institute of Mental Health 2016d)

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The ability of the melatonin cycle to adjust circadian biology is also consistent with the observations that the diminished melatonin levels in the aged are associated with generalized chronodisruption ( Surgical removal of the pineal gland in mammals is usually associated with essentially an absence of blood melatonin levels with no discernible rhythm