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3 Adverse events in PIONEER 2 1,3 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Because clinical trials are conducted under widely varying conditions, AE rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 AE=adverse event

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Thus, in general, drug absorption may be dissolution rate-limited or permeation rate-limited.