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Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig

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doi: 10.1177/1060028020929988 53 El NouwarR.PrevostB.WautierM.YinN.HitesM.MartinyD

Studies demonstrated that type I interferon enhances manganese-induced ferroptosis sensitivity by downregulating mitochondrial DHODH, elucidating the underlying molecular mechanism