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Ozempic Face: The Effects of GLP-1 and Weight Loss on Facial Skin and Contours GLP-1 medications like Ozempic and Wegovy were originally developed to treat Type 2 diabetes

going significantly longer than 8 days between injections may reduce medication continuity

There is also the risk of long-term bone density loss, possibly resulting in fractured bones

Additionally, nuclear receptor coactivator 4 (NCOA4) binds to ferritin and promotes ferritinophagy, releasing labile Fe 2+ into the LIP and facilitating ferroptosis

The increased cost and additional injection requirement mean the combination approach represents a step up in commitment