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The chemopreventive benefit was limited to patients who initiated GLP-1 RAs earlier in the disease course

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Given the extensive 15-year clinical experience with GLP-1R agonists, including an established safety profile in cardiovascular disease settings, this review will consider whether complementary mechanisms of action, when combined with GLP-1, might be effective yet safe new agents that are superior to GLP-1R agonists alone as therapy for metabolic disorders