Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR, Deng C-X, Hanawalt PC, Fornace AJ
SOD is used in cosmetics and personal care products as an anti-aging ingredient and antioxidant due to its ability to reduce free radical damage to the skin, therefore preventing wrinkles, fine lines, and age spots, and it also helps with wound healing, softens scar tissue, protects against UV rays, and reduces other signs of aging.[10] It has been reported that SOD has an important link in several human health problems including RBC-related disorders, cystic fibrosis (CF), postcholecystectomy pain syndrome, malignant breast disease, steroid-sensitive nephrotic syndrome, amyotrophic lateral sclerosis, neuronal apoptosis, AIDS, and cancer.[8,11-16] Furthermore, a strong association between the activity of SOD and Alzheimers disease has been suggested by some researchers.[8] It has also been reported that treatment with SOD helps recovery from mustard gas burns.[17] In many animal models having myocardial ischemia-reperfusion injury, inflammation, and cerebral ischemia-reperfusion injury, etc., SOD enzymes are found to be very effective.[18] SOD mimetics (small molecule catalytic antioxidants) offer a potential for treating diseases resulting from oxidative stress
[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Qi T., Xu F., Yan X., Li S., Li H
Imaging is essential to determine tear extent before pursuing conservative treatment
The original clinical development, by the Canadian biotech ConjuChem, was discontinued, and there is no validated disease endpoint for either version
